Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation

• Published in: Cancer research (Chicago, Ill.) Vol. 78; no. 3; pp. 659 - 670
• Main Authors: Tommelein, Joke, De Vlieghere, Elly, Verset, Laurine, Melsens, Elodie, Leenders, Justine, Descamps, Benedicte, Debucquoy, Annelies, Vanhove, Christian, Pauwels, Patrick, Gespach, Christian P., Vral, Anne, De Boeck, Astrid, Haustermans, Karin, de Tullio, Pascal, Ceelen, Wim, Demetter, Pieter, Boterberg, Tom, Bracke, Marc, De Wever, Olivier
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 01.02.2018; American Association for Cancer Research
• Subjects: Animal models; Cell activation; Chemoradiotherapy; Colorectal cancer; Colorectal carcinoma; DNA damage; Fibroblasts; Gene expression; Glutamine; Insulin; Insulin-like growth factor I; Life Sciences; Metastases; p53 Protein; Paracrine signalling; Radiation therapy; Rectum; Secretion; Stroma; TOR protein

Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAFs are abundantly present, the effects of RT to CAF and its impact on cancer cells are unknown. We evaluated the da...