Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study
Abstract Background Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal outcome remain sparsely investigated. Methods A retrospective cohort study was performed in a cohort of patients with con...
Saved in:
Published in | Clinical Infectious Diseases Vol. 72; no. 4; pp. 626 - 633 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article Web Resource |
Language | English |
Published |
US
Oxford University Press
16.02.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
Background
Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal outcome remain sparsely investigated.
Methods
A retrospective cohort study was performed in a cohort of patients with confirmed COVID-19 in one designated hospital in Wuhan, China, from 17 January–5 March 2020. The laboratory parameters and a panel of cytokines were consecutively evaluated until patients’ discharge or death. The laboratory features that could be used to predict fatal outcome were identified.
Results
Consecutively collected data on 55 laboratory parameters and cytokines from 642 patients with COVID-19 were profiled along the entire disease course, based on which 3 clinical stages (acute stage, days 1–9; critical stage, days 10–15; and convalescence stage, day 15 to observation end) were determined. Laboratory findings based on 75 deceased and 357 discharged patients revealed that, at the acute stage, fatality could be predicted by older age and abnormal lactate dehydrogenase (LDH), urea, lymphocyte count, and procalcitonin (PCT) level. At the critical stage, the fatal outcome could be predicted by age and abnormal PCT, LDH, cholinesterase, lymphocyte count, and monocyte percentage. Interleukin 6 (IL-6) was remarkably elevated, with fatal cases having a more robust production than discharged cases across the whole observation period. LDH, PCT, lymphocytes, and IL-6 were considered highly important prognostic factors for COVID-19–related death.
Conclusions
The identification of predictors that were routinely tested might allow early identification of patients at high risk of death for early aggressive intervention.
A full description of the laboratory abnormalities for coronavirus disease 2019 (COVID-19) is reported, based on which 3 clinical stages of the disease were defined and their application in predicting fatal COVID-19 was explored. |
---|---|
AbstractList | BACKGROUNDPatients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal outcome remain sparsely investigated. METHODSA retrospective cohort study was performed in a cohort of patients with confirmed COVID-19 in one designated hospital in Wuhan, China, from 17 January-5 March 2020. The laboratory parameters and a panel of cytokines were consecutively evaluated until patients' discharge or death. The laboratory features that could be used to predict fatal outcome were identified. RESULTSConsecutively collected data on 55 laboratory parameters and cytokines from 642 patients with COVID-19 were profiled along the entire disease course, based on which 3 clinical stages (acute stage, days 1-9; critical stage, days 10-15; and convalescence stage, day 15 to observation end) were determined. Laboratory findings based on 75 deceased and 357 discharged patients revealed that, at the acute stage, fatality could be predicted by older age and abnormal lactate dehydrogenase (LDH), urea, lymphocyte count, and procalcitonin (PCT) level. At the critical stage, the fatal outcome could be predicted by age and abnormal PCT, LDH, cholinesterase, lymphocyte count, and monocyte percentage. Interleukin 6 (IL-6) was remarkably elevated, with fatal cases having a more robust production than discharged cases across the whole observation period. LDH, PCT, lymphocytes, and IL-6 were considered highly important prognostic factors for COVID-19-related death. CONCLUSIONSThe identification of predictors that were routinely tested might allow early identification of patients at high risk of death for early aggressive intervention. A full description of the laboratory abnormalities for coronavirus disease 2019 (COVID-19) is reported, based on which 3 clinical stages of the disease were defined and their application in predicting fatal COVID-19 was explored. Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal outcome remain sparsely investigated. A retrospective cohort study was performed in a cohort of patients with confirmed COVID-19 in one designated hospital in Wuhan, China, from 17 January-5 March 2020. The laboratory parameters and a panel of cytokines were consecutively evaluated until patients' discharge or death. The laboratory features that could be used to predict fatal outcome were identified. Consecutively collected data on 55 laboratory parameters and cytokines from 642 patients with COVID-19 were profiled along the entire disease course, based on which 3 clinical stages (acute stage, days 1-9; critical stage, days 10-15; and convalescence stage, day 15 to observation end) were determined. Laboratory findings based on 75 deceased and 357 discharged patients revealed that, at the acute stage, fatality could be predicted by older age and abnormal lactate dehydrogenase (LDH), urea, lymphocyte count, and procalcitonin (PCT) level. At the critical stage, the fatal outcome could be predicted by age and abnormal PCT, LDH, cholinesterase, lymphocyte count, and monocyte percentage. Interleukin 6 (IL-6) was remarkably elevated, with fatal cases having a more robust production than discharged cases across the whole observation period. LDH, PCT, lymphocytes, and IL-6 were considered highly important prognostic factors for COVID-19-related death. The identification of predictors that were routinely tested might allow early identification of patients at high risk of death for early aggressive intervention. Abstract Background Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal outcome remain sparsely investigated. Methods A retrospective cohort study was performed in a cohort of patients with confirmed COVID-19 in one designated hospital in Wuhan, China, from 17 January–5 March 2020. The laboratory parameters and a panel of cytokines were consecutively evaluated until patients’ discharge or death. The laboratory features that could be used to predict fatal outcome were identified. Results Consecutively collected data on 55 laboratory parameters and cytokines from 642 patients with COVID-19 were profiled along the entire disease course, based on which 3 clinical stages (acute stage, days 1–9; critical stage, days 10–15; and convalescence stage, day 15 to observation end) were determined. Laboratory findings based on 75 deceased and 357 discharged patients revealed that, at the acute stage, fatality could be predicted by older age and abnormal lactate dehydrogenase (LDH), urea, lymphocyte count, and procalcitonin (PCT) level. At the critical stage, the fatal outcome could be predicted by age and abnormal PCT, LDH, cholinesterase, lymphocyte count, and monocyte percentage. Interleukin 6 (IL-6) was remarkably elevated, with fatal cases having a more robust production than discharged cases across the whole observation period. LDH, PCT, lymphocytes, and IL-6 were considered highly important prognostic factors for COVID-19–related death. Conclusions The identification of predictors that were routinely tested might allow early identification of patients at high risk of death for early aggressive intervention. A full description of the laboratory abnormalities for coronavirus disease 2019 (COVID-19) is reported, based on which 3 clinical stages of the disease were defined and their application in predicting fatal COVID-19 was explored. |
Author | Zeng, Hao-Long Yue, Dao-Yuan Zhang, Lei-Ke Wang, Xu Li, Hui-Jun Liu, Wei Li, Hao Lu, Qing-Bin Yang, Qing |
AuthorAffiliation | 4 State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China 3 Institute of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, China 5 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, China 1 Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China 2 Department of Laboratorial Science and Technology, School of Public Health, Peking University , Beijing, China |
AuthorAffiliation_xml | – name: 1 Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China – name: 3 Institute of Food Science and Engineering, Wuhan Polytechnic University , Wuhan, China – name: 5 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, China – name: 2 Department of Laboratorial Science and Technology, School of Public Health, Peking University , Beijing, China – name: 4 State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China |
Author_xml | – sequence: 1 givenname: Hao-Long surname: Zeng fullname: Zeng, Hao-Long organization: Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China – sequence: 2 givenname: Qing-Bin orcidid: 0000-0002-2804-0827 surname: Lu fullname: Lu, Qing-Bin organization: Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China – sequence: 3 givenname: Qing surname: Yang fullname: Yang, Qing organization: Institute of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, China – sequence: 4 givenname: Xu surname: Wang fullname: Wang, Xu organization: Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China – sequence: 5 givenname: Dao-Yuan surname: Yue fullname: Yue, Dao-Yuan organization: Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China – sequence: 6 givenname: Lei-Ke surname: Zhang fullname: Zhang, Lei-Ke organization: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China – sequence: 7 givenname: Hao surname: Li fullname: Li, Hao email: liuwei@bmi.ac.cn organization: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China – sequence: 8 givenname: Wei surname: Liu fullname: Liu, Wei email: liuwei@bmi.ac.cn organization: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China – sequence: 9 givenname: Hui-Jun surname: Li fullname: Li, Hui-Jun email: liuwei@bmi.ac.cn organization: Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33048116$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kt1r1TAYxoNM3IdeeS8BQQSpJs1H010I5bDp4MDGztTLkqZv14w2qWk6OH_U_kej5zjUCy_yQd5fnjzkeY_RgfMOEHpJyXtKSvbB2DYNrUXBn6AjKliRSVHSg7QnQmVcMXWIjuf5jhBKFRHP0CFjhCtK5RF6WHt3a-PSWqcHfBV8ZwfAvsNr3figow9bfKWDHiFCmLF2Lb7pwQZcTdNgjY7WO2wdjj2k29Ba8-uk8wGf65gkL5do_Ai4GtNDSSpacHHGF64DE6HF32zs8aa63mQr_zXLT3GFryEGP0-pbu8Br3zvQ8Sb5HH7HD3t9DDDi_16gr6cn92sPmfry08Xq2qdGc5JzIoCDGeyAZkXnZDKNNx0umgpMYLoJpfAiCFG54pRqZSSnKa55ExpJXTD2An6uNOdlmaE1iTLQQ_1FOyow7b22tZ_V5zt61t_XxdSClYWSeDtXiD47wvMsR7tbGAYtAO_zHXOBZEpAqUS-vof9M4vIaWxp0pJKEnUux1l0tfMAbpHM5TUP9ugTm1Q79sg0a_-9P_I_s49AW92gF-m_yr9ABWRv5g |
CitedBy_id | crossref_primary_10_1016_j_bja_2023_04_008 crossref_primary_10_1016_j_bios_2021_113439 crossref_primary_10_1021_acs_jproteome_1c00538 crossref_primary_10_1371_journal_pcbi_1009778 crossref_primary_10_1177_11297298241234073 crossref_primary_10_1186_s12879_021_05792_7 crossref_primary_10_1113_EP089474 crossref_primary_10_1002_jmv_26713 crossref_primary_10_1007_s40211_023_00487_8 crossref_primary_10_3389_fmed_2022_852749 crossref_primary_10_3390_jcm12196264 crossref_primary_10_3390_pathogens11050563 |
Cites_doi | 10.1016/S0140-6736(20)30211-7 10.1016/S2213-2600(20)30079-5 10.1093/ajcn/nqz103 10.1016/S0140-6736(20)30566-3 10.1007/s11427-020-1643-8 10.1111/jth.14768 10.1148/radiol.2020200280 10.1056/NEJMoa2001316 10.1056/NEJMoa2001017 10.1016/S0140-6736(20)30154-9 10.1001/jamainternmed.2020.0994 10.1007/s40520-020-01498-z 10.1001/jama.2020.1585 10.1016/S0140-6736(20)30183-5 10.1016/j.ijsu.2020.02.034 |
ContentType | Journal Article Web Resource |
Copyright | The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://academic.oup.com/journals/pages/coronavirus . |
Copyright_xml | – notice: The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020 – notice: The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. – notice: 2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://academic.oup.com/journals/pages/coronavirus . |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION COVID 7X8 5PM |
DOI | 10.1093/cid/ciaa574 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Coronavirus Research Database MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Coronavirus Research Database MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: COVID name: Coronavirus Research Database url: https://proxy.k.utb.cz/login?url=https://search.proquest.com/coronavirus sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1537-6591 |
EndPage | 633 |
ExternalDocumentID | 10_1093_cid_ciaa574 33048116 10.1093/cid/ciaa574 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | China |
GeographicLocations_xml | – name: China |
GrantInformation_xml | – fundername: ; ; grantid: 2018ZX10713002; 2018ZX10101003; 2017ZX10103004 – fundername: ; ; grantid: 81825019 |
GroupedDBID | --- ..I .2P .GJ .I3 .ZR 08P 0R~ 1KJ 1TH 29B 2AX 2WC 36B 3O- 4.4 48X 53G 5GY 5RE 5VS 5WD 6.Y 6J9 70D AABZA AACGO AACZT AAJKP AAJQQ AAMVS AANCE AAOGV AAPGJ AAPNW AAPQZ AAPXW AAQQT AARHZ AASNB AAUAY AAUQX AAVAP AAWDT AAYOK ABBHK ABEUO ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPLY ABPTD ABQLI ABQNK ABSAR ABSMQ ABTLG ABWST ABXSQ ABXVV ABZBJ ACFRR ACGFO ACGFS ACMRT ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ACZBC ADACV ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADULT ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFNX AFFZL AFIYH AFOFC AFRAH AFSHK AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHXPO AI. AIAGR AIJHB AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APJGH APWMN AQDSO AQKUS AQVQM ASPBG ATGXG AVNTJ AVWKF AXUDD AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM BZKNY C1A C45 CDBKE CS3 CZ4 DAKXR DCCCD DIK DILTD DOOOF DU5 D~K E3Z EBS EE~ EIHJH EJD EMOBN ENERS ESX F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC H13 H5~ HAR HQ3 HTVGU HVGLF HW0 HZ~ IOX IPSME J21 J5H JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KAQDR KBUDW KOP KSI KSN L7B M49 MBLQV MHKGH MJL ML0 N4W N9A NGC NOMLY NOYVH NU- NVLIB O0~ O9- OAUYM OAWHX OCZFY ODMLO ODZKP OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P P6G PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TMA TR2 VH1 W8F X7H Y6R YAYTL YKOAZ YXANX ZGI ~91 ~S- CGR CUY CVF ECM EIF NPM AAYXX ABEJV CITATION COVID 7X8 5PM |
ID | FETCH-LOGICAL-c440t-77ec436be627f568cb4cfa7d10c50ab26e30c0ca283168886418889438a85ab33 |
IEDL.DBID | COVID |
ISSN | 1058-4838 |
IngestDate | Tue Sep 17 21:22:14 EDT 2024 Wed Dec 04 07:11:42 EST 2024 Thu Oct 10 20:15:15 EDT 2024 Fri Dec 06 01:16:22 EST 2024 Wed Oct 16 00:41:24 EDT 2024 Wed Aug 28 03:17:54 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | COVID-19 SARS-CoV-2 China fatal outcome |
Language | English |
License | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c440t-77ec436be627f568cb4cfa7d10c50ab26e30c0ca283168886418889438a85ab33 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 W. L. and H-J. Li. equally contributed as co-corresponding authors. H.-L. Z. and Q.-B. L. contributed equally to this work. |
ORCID | 0000-0002-2804-0827 |
OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7665397 |
PMID | 33048116 |
PQID | 2450696010 |
PQPubID | 4686267 |
PageCount | 8 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7665397 proquest_miscellaneous_2450648188 proquest_journals_2450696010 crossref_primary_10_1093_cid_ciaa574 pubmed_primary_33048116 oup_primary_10_1093_cid_ciaa574 |
PublicationCentury | 2000 |
PublicationDate | 2021-02-16 |
PublicationDateYYYYMMDD | 2021-02-16 |
PublicationDate_xml | – month: 02 year: 2021 text: 2021-02-16 day: 16 |
PublicationDecade | 2020 |
PublicationPlace | US |
PublicationPlace_xml | – name: US – name: United States – name: Oxford |
PublicationTitle | Clinical Infectious Diseases |
PublicationTitleAlternate | Clin Infect Dis |
PublicationYear | 2021 |
Publisher | Oxford University Press |
Publisher_xml | – name: Oxford University Press |
References | Sohrabi (2021021605263071300_CIT0013) 2020; 76 Wu (2021021605263071300_CIT0007) 2020 Kong (2021021605263071300_CIT0021) 2017; 33 Fang (2021021605263071300_CIT0005) 2020; 295 (2021021605263071300_CIT0012) 2020 Yang (2021021605263071300_CIT0015) 2020 Wang (2021021605263071300_CIT0009) 2020; 323 Li (2021021605263071300_CIT0019) 2020 Zhou (2021021605263071300_CIT0008) 2020; 395 National Health Commission of the People’s Republic of China (2021021605263071300_CIT0014) Li (2021021605263071300_CIT0002) 2020; 382 Ruan (2021021605263071300_CIT0016) 2020 Liu (2021021605263071300_CIT0020) 2019; 48 Chen (2021021605263071300_CIT0003) 2020; 395 Chan (2021021605263071300_CIT0004) 2020; 395 Zhang (2021021605263071300_CIT0011) 2020 Madjid (2021021605263071300_CIT0022) Tang (2021021605263071300_CIT0017) 2020 Liu (2021021605263071300_CIT0006) 2020; 63 Huang (2021021605263071300_CIT0010) 2020; 395 Zhu (2021021605263071300_CIT0001) 2020; 382 Seo (2021021605263071300_CIT0018) 2019; 110 |
References_xml | – volume: 395 start-page: 507 year: 2020 ident: 2021021605263071300_CIT0003 article-title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study publication-title: Lancet doi: 10.1016/S0140-6736(20)30211-7 contributor: fullname: Chen – year: 2020 ident: 2021021605263071300_CIT0015 article-title: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(20)30079-5 contributor: fullname: Yang – volume: 110 start-page: 330 year: 2019 ident: 2021021605263071300_CIT0018 article-title: Prognostic significance of serum cholinesterase in patients with acute decompensated heart failure: a prospective comparative study with other nutritional indices publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqz103 contributor: fullname: Seo – year: 2020 ident: 2021021605263071300_CIT0011 article-title: Clinical characteristics of 82 death cases with COVID-19 publication-title: medRxiv contributor: fullname: Zhang – volume: 395 start-page: 1054 year: 2020 ident: 2021021605263071300_CIT0008 article-title: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study publication-title: Lancet doi: 10.1016/S0140-6736(20)30566-3 contributor: fullname: Zhou – volume: 63 start-page: 364 year: 2020 ident: 2021021605263071300_CIT0006 article-title: Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury publication-title: Sci China Life Sci doi: 10.1007/s11427-020-1643-8 contributor: fullname: Liu – year: 2020 ident: 2021021605263071300_CIT0017 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost doi: 10.1111/jth.14768 contributor: fullname: Tang – volume: 295 start-page: 208 year: 2020 ident: 2021021605263071300_CIT0005 article-title: CT Manifestations of two cases of 2019 novel coronavirus (2019-nCoV) pneumonia publication-title: Radiology doi: 10.1148/radiol.2020200280 contributor: fullname: Fang – ident: 2021021605263071300_CIT0014 contributor: fullname: National Health Commission of the People’s Republic of China – volume: 382 start-page: 1199 year: 2020 ident: 2021021605263071300_CIT0002 article-title: Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia publication-title: N Engl J Med doi: 10.1056/NEJMoa2001316 contributor: fullname: Li – volume: 48 start-page: 158 year: 2019 ident: 2021021605263071300_CIT0020 article-title: Levels of serum cholinesterase and prealbumin in patients with chronic obstructive pulmonary disease with respiratory failure and their relationships with prognosis publication-title: J Med Res contributor: fullname: Liu – volume: 382 start-page: 727 year: 2020 ident: 2021021605263071300_CIT0001 article-title: A novel coronavirus from patients with pneumonia in China, 2019 publication-title: N Engl J Med doi: 10.1056/NEJMoa2001017 contributor: fullname: Zhu – year: 2020 ident: 2021021605263071300_CIT0016 article-title: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China publication-title: Intensive Care Med contributor: fullname: Ruan – ident: 2021021605263071300_CIT0022 article-title: Potential effects of coronaviruses on the cardiovascular system: a review publication-title: JAMA Cardiol contributor: fullname: Madjid – volume: 33 start-page: 1806 year: 2017 ident: 2021021605263071300_CIT0021 article-title: Value of serum cholinesterase in diagnosis /treatment and prognostic evaluation of liver diseases publication-title: J Clin Hepatol contributor: fullname: Kong – volume: 395 start-page: 514 year: 2020 ident: 2021021605263071300_CIT0004 article-title: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster publication-title: Lancet doi: 10.1016/S0140-6736(20)30154-9 contributor: fullname: Chan – year: 2020 ident: 2021021605263071300_CIT0007 article-title: risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2020.0994 contributor: fullname: Wu – year: 2020 ident: 2021021605263071300_CIT0019 article-title: Admission serum cholinesterase concentration for prediction of in-hospital mortality in very elderly patients with acute ischemic stroke: a retrospective study publication-title: Aging Clin Exp Res doi: 10.1007/s40520-020-01498-z contributor: fullname: Li – volume: 323: start-page: 1061 year: 2020 ident: 2021021605263071300_CIT0009 article-title: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China publication-title: JAMA doi: 10.1001/jama.2020.1585 contributor: fullname: Wang – volume: 395 start-page: 497 year: 2020 ident: 2021021605263071300_CIT0010 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 contributor: fullname: Huang – year: 2020 ident: 2021021605263071300_CIT0012 article-title: The novel coronavirus outbreak: what we know and what we don’t publication-title: Cell – volume: 76 start-page: 71 year: 2020 ident: 2021021605263071300_CIT0013 article-title: World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19) publication-title: Int J Surg doi: 10.1016/j.ijsu.2020.02.034 contributor: fullname: Sohrabi |
SSID | ssj0011805 |
Score | 2.4707806 |
Snippet | Abstract
Background
Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The... Patients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors for fatal... BACKGROUNDPatients with coronavirus disease 2019 (COVID-19) experience a wide clinical spectrum, with over 2% developing fatal outcome. The prognostic factors... A full description of the laboratory abnormalities for coronavirus disease 2019 (COVID-19) is reported, based on which 3 clinical stages of the disease were... |
SourceID | pubmedcentral proquest crossref pubmed oup |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 626 |
SubjectTerms | Aged China - epidemiology COVID-19 - mortality Humans Laboratories Major Prognosis Retrospective Studies SARS-CoV-2 |
Title | Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/33048116 https://www.proquest.com/docview/2450696010 https://search.proquest.com/docview/2450648188 https://pubmed.ncbi.nlm.nih.gov/PMC7665397 |
Volume | 72 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagvSAOgHiFljJIvaZ1EsdOekGrhVUXCq3o8xY5jqNdIcVlNzmU_8R_ZCaPbbeHHrjsIXGyjmacfPPw9zG2q4URubEFWsAYX4Q69RNTcj80QWxtWoiy5dL7_kMenouvV_FVn3Bb9m2VwzuxfVEXzlCOfD8UMZcphQ-frn_7pBpF1dVeQuMx24wQOqCHb46PL6af-414GK3vG7QpPqWOlVj79KxtZ7uDKu83R9752kyesWyYZ9dk8muvqfM98-ceheP_P8hz9vTS5jCk7l-wR7Z6yf4eORIvagoSyoKTTswbXAlHnaO4xQ2caGrmIkZO0FUBZ1RmgNFtERzmFSCkxKupANQeQVQME0oSwXFT4xQtjEjgCG_VMrouYdr2g9kCLuf1DE5HP0_9sbvwwwMY4RTrhRt2g8LYzTBaAOp9vHnFzidfzsaHfq_m4BsheI0w3hoRydzKUJWxTEwuTKlVEXATc52H0kbccKMR7wQS43IpAvxNRZToJNZ5FL1mG5Wr7FsGKom0KRC9JKUivq6U50qpQBexRXyrucd2B0Nn1x1pR9YV26OMlIp7f_DYB3SCh0dsDzbM-rW9zG4N6LGPq9O4KqnUoivrmn6MQDCUeOxN50-r_6EMUhIE0mNqzdNWA4jxe_1MNZ-1zN9KEpOwevfwtLbYk5A6b0i2Rm6zjXrR2PcInep8p18fOxg8TL_9AyCrIvo |
link.rule.ids | 230,314,780,784,885,27924,27925,38516,43895 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswECVa59Cih6boEqVJMwVyVaKFIqVeCsOpYbfOgsZZbgJFUbBRQEps6ZD-U_8xM1qcOIccetFBoiQSM5QeZ4bvMbavuOaJNilaQGubeyqyQ505tqfdwJgo5VnNpXd8IkYX_Od1cN0G3JZtWWX3Taw_1GmhKUZ-6PHAEREtH77f3NqkGkXZ1VZC4yXbIBXvoMc2BqeX46N2Ix6u1g812hRHqQLJ1349a9vZHqHKp8WRj_42w7cs7vrZFJn8OajK5ED_fULh-P8D2WRvrkwCXej-HXth8vfs36Qg8aIqJaEsOGvEvKHIYNI4SrG4gzNFxVzEyAkqT2FKaQboPyTBYZ4DQkq8mxJA9RlExTCkIBGcViV20UCfBI7wUTWj6xLGdT2YSeFqXs7gvP_73B4Ul7b3DfrYxXJRdLtBYVDMcLUAVPt494FdDH9MByO7VXOwNedOiTDeaO6LxAhPZoEIdcJ1pmTqOjpwVOIJ4zva0QrxjitwXS64i8cI7arCQCW-_5H18iI3Wwxk6CudInoJM0l8XZGTSCldlQYG8a1yLLbfGTq-aUg74ibZ7sekVNz6g8X20Ameb7HT2TBu5_YyfjCgxb6uLuOspFSLyk1RtW04gqHQYp8af1q9hyJIoesKi8k1T1s1IMbv9Sv5fFYzf0tBTMJy-_lu7bFXo-nxJJ6MT359Zq89qsIhCRuxw3rlojK7CKPK5Es7V-4BHRIk8Q |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Longitudinal+Profile+of+Laboratory+Parameters+and+Their+Application+in+the+Prediction+for+Fatal+Outcome+Among+Patients+Infected+With+SARS-CoV-2%3A+A+Retrospective+Cohort+Study&rft.jtitle=Clinical+infectious+diseases&rft.au=Zeng%2C+Hao-Long&rft.au=Lu%2C+Qing-Bin&rft.au=Yang%2C+Qing&rft.au=Wang%2C+Xu&rft.date=2021-02-16&rft.pub=Oxford+University+Press&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093%2Fcid%2Fciaa574&rft_id=info%3Apmid%2F33048116&rft.externalDBID=PMC7665397 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1058-4838&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1058-4838&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1058-4838&client=summon |