Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage - Manczak, Maria; Calkins, Marcus J.; Reddy, P. Hemachandra (Human molecular genetics, 2011)
Keywords: Aged; Aged, 80 and over; Alzheimer Disease - physiopathology; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; Biological and medical sciences; Cyclooxygenase 1 - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Dynamins; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - genetics; Genes, Mitochondrial - genetics; Genetics of eukaryotes. Biological and molecular evolution; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Humans; Male; Medical sciences; Mice; Mice, Transgenic; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Mitochondria - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Molecular and cellular biology; Neurology; Neurons - metabolism; Neurons - pathology; Protein Binding; Protein Transport - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Human; Nervous system diseases; Alzheimer disease; Protein; Chenopodiaceae; Cerebral disorder; Beta; Mitochondria; Neuron; Dynamics; Dicotyledones; Angiospermae; Central nervous system disease; Genetics; Degenerative disease; Spermatophyta; Amyloid; Lesion