Intron Disruption of the Annexin IV Gene Reveals Novel Transcripts

• Published in: The Journal of biological chemistry Vol. 278; no. 44; pp. 43276 - 43283
• Main Authors: Li, Bailing, Dedman, John R., Kaetzel, Marcia A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.10.2003; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Annexin A4 - genetics; Annexin A4 - metabolism; Blotting, Northern; Calcium - metabolism; DNA, Complementary - metabolism; Immunoblotting; Immunohistochemistry; Intestinal Mucosa - metabolism; Intestine, Small - metabolism; Introns; Kidney - metabolism; Lipid Bilayers - metabolism; Mice; Models, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Tissue Distribution

Annexin IV (AIV), a Ca2+-dependent membrane-binding protein, is expressed in many epithelia. Annexin IV modifies membrane bilayers by increasing rigidity, reducing water and H+ permeability, promoting vesicle aggregation, and regulating ion conductances, all in a Ca2+-dependent manner. We have chara...