Rapamycin Ameliorates Neuropathic Pain by Activating Autophagy and Inhibiting Interleukin-1β in the Rat Spinal Cord

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 34; no. 6; pp. 830 - 837
• Main Author: 冯涛 殷琴 翁泽林 张建成 王昆锋 袁世荧 程伟
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.12.2014; Department of Anesthesiology and Intensive Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Anesthesiology, Xixiang people's Hospital of Bao'an District, Shenzhen 518100, China%Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment, Jiangsu Province Key Laboratory of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China%Department of Anesthesiology and Intensive Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%Department of Anesthesiology, Xixiang people's Hospital of Bao'an District, Shenzhen 518100, China
• Subjects: Animals; Autophagy - drug effects; Immunosuppressive Agents; Interleukin-1beta - antagonists & inhibitors; Interleukin-1beta - metabolism; Male; Medicine; Medicine & Public Health; Neuralgia - drug therapy; Neuralgia - metabolism; Neuralgia - pathology; Rats; Rats, Sprague-Dawley; RNA, Messenger - metabolism; Sirolimus - pharmacology; Spine - metabolism; Spine - pathology; 大鼠; 激活; 疼痛; 白细胞介素-1; 脊神经; 脊髓; 自噬; 雷帕霉素; neuropathic pain; autophagy; rapamycin; interleukin-1β

Autophagy acts as an important homoeostatic mechanism by degradation of cytosolic con- stituents and plays roles in many physiological processes. Recent studies demonstrated that autophagy can also regulate the production and secretion of the proinflammatory cytokine interleukin-1β （IL-1β）, which pl...