Dissociative Properties of the Proteins within the Bacteriophage T4 Replisome

• Published in: The Journal of biological chemistry Vol. 278; no. 50; pp. 49839 - 49849
• Main Authors: Trakselis, Michael A., Roccasecca, Rosa Maria, Yang, Jingsong, Valentine, Ann M., Benkovic, Stephen J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.12.2003; American Society for Biochemistry and Molecular Biology
• Subjects: Adenosine Triphosphatases - chemistry; Bacteriophage T4 - enzymology; Bacteriophage T7 - metabolism; Calorimetry; Catalysis; DNA - chemistry; DNA Replication; DNA-Directed DNA Polymerase - chemistry; DNA-Directed DNA Polymerase - genetics; Escherichia coli - enzymology; Escherichia coli - metabolism; Genes, Dominant; Models, Chemical; Models, Genetic; Nucleic Acid Conformation; Phage T4; Protein Binding; Templates, Genetic; Time Factors

DNA replication is a highly processive and efficient process that involves the coordination of at least eight proteins to form the replisome in bacteriophage T4. Replication of DNA occurs in the 5′ to 3′ direction resulting in continuous replication on the leading strand and discontinuous replicatio...