Acute and Chronic Increases of Circulating FSTL1 Normalize Energy Substrate Metabolism in Pacing-Induced Heart Failure

• Published in: Circulation. Heart failure Vol. 11; no. 1; p. e004486
• Main Authors: Seki, Mitsuru, Powers, Jeffery C., Maruyama, Sonomi, Zuriaga, Maria A., Wu, Chia-Ling, Kurishima, Clara, Kim, Lydia, Johnson, Jesse, Poidomani, Anthony, Wang, Tao, Muñoz, Eric, Rajan, Sudarsan, Park, Joon Y., Walsh, Kenneth, Recchia, Fabio A.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: heart failure; glucose; myocardium; animals; heart

FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and is found to be cardioprotective in animal models of cardiac injury. We tested the hypothesis that circulating FSTL1 can affect cardiac function and metabolism under baseline physiologic...