Glutamatergic regulation of brain histamine neurons: In vivo microdialysis and electrophysiology studies in the rat

• Published in: Neuropharmacology Vol. 99; pp. 1 - 8
• Main Authors: Fell, Matthew J., Flik, Gunnar, Dijkman, Ulrike, Folgering, Joost H.A., Perry, Kenneth W., Johnson, Bryan J., Westerink, Ben H.C., Svensson, Kjell A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2015
• Subjects: Animals; Brain - drug effects; Brain - physiology; Circadian rhythm; Circadian Rhythm - physiology; Electrophysiology; Excitatory Amino Acid Agonists - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; gamma-Aminobutyric Acid - metabolism; Glutamatergic system; Glutamic Acid - metabolism; Histamine; Histamine - metabolism; Male; Microdialysis; Microelectrodes; Neurons - drug effects; Neurons - physiology; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate - agonists; Receptors, Metabotropic Glutamate - antagonists & inhibitors; Receptors, Metabotropic Glutamate - metabolism; Receptors, N-Methyl-D-Aspartate - agonists; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; LY379268; PubChem CID:3035905; PubChem CID:3272524; PubChem CID:9864510; Electrophysiology; PubChem CID:3035842; mGluR; PubChem CID:774; NAc; Thioperamide; PubChem CID not found; Glutamatergic system; NMDA; PubChem CID:6324636; Circadian rhythm; Immepip; LY366457; PubChem CID:44322701; PH-TMN; Histamine; mPFC; Microdialysis; CBiPES; LY341495; vHipp; NBQX; PubChem CID:22880

The interactions between the glutamatergic and the histaminergic systems in the brain are not fully understood. Here we studied histamine release in the medial prefrontal cortex and the posterior hypothalamus-tuberomamillary nucleus (PH-TMN) using in vivo microdialysis and electrophysiological recor...