Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets

• Published in: Briefings in bioinformatics Vol. 22; no. 2; pp. 1279 - 1290
• Main Authors: Li, Rong, Li, Yu, Liang, Xiao, Yang, Lu, Su, Min, Lai, Keng Po
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.03.2021; Oxford Publishing Limited (England)
• Subjects: Aged; Binding; Bioinformatics; Case Study; Colorectal carcinoma; Colorectal Neoplasms - genetics; Computational Biology; Computer applications; Computer programs; Coronaviruses; COVID-19; COVID-19 - drug therapy; COVID-19 - virology; Female; Functionals; Genes; Humans; Inflammation; Interleukin 1; Male; Medical prognosis; Microenvironments; Middle Aged; Molecular docking; Molecular Docking Simulation; Niacin - pharmacology; Niacin - therapeutic use; Nicotinic acid; Pandemics; Patients; Pharmacology; SARS-CoV-2 - drug effects; Survival; Viral diseases; Vitamin B; COVID-19; computational biology; niacin; network pharmacology; prognosis; colorectal neoplasms

Abstract Objectives Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently unavailable. Since niacin is a vitamin with cytoprotective and anti-inflammatory functions, this study aimed to evaluate...