Different pre-S deletion patterns and their association with hepatitis B virus genotypes

• Published in: World journal of gastroenterology : WJG Vol. 22; no. 35; pp. 8041 - 8049
• Main Author: Chen, Bing-Fang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.09.2016
• Subjects: Adult; Basic Study; Carcinoma, Hepatocellular - virology; Cloning, Molecular; Disease Progression; DNA, Viral - genetics; Female; Gene Deletion; Genotype; Hepatitis B Surface Antigens - blood; Hepatitis B Surface Antigens - genetics; Hepatitis B virus - genetics; Hepatitis B, Chronic - virology; Humans; Liver Cirrhosis - virology; Liver Neoplasms - virology; Male; Middle Aged; Mutation; Sequence Analysis, DNA; Viral Load; Genotype; Hepatocellular carcinoma; Hepatitis B virus; Liver cirrhosis; Chronic hepatitis; Pre-S deletion

AIM To investigate the associations of different types of pre-S deletions with hepatitis B virus(HBV) genotypes.METHODS The sequences of the pre-S region, basal core promoter(BCP) mutation, and precore(PC) mutation were examined through direct DNA sequencing or clonal analysis and sequencing in 273...