Fyn Is Downstream of the HGF/MET Signaling Axis and Affects Cellular Shape and Tropism in PC3 Cells

• Published in: Clinical cancer research Vol. 17; no. 10; pp. 3112 - 3122
• Main Authors: Jensen, Ana R., David, Saito Y., Liao, Chuanhong, Dai, Jinlu, Keller, Evan T., Al-Ahmadie, Hikmat, Dakin-Haché, Kelly, Usatyuk, Peter, Sievert, Margarit F., Paner, Gladell P., Yala, Soheil, Cervantes, Gustavo M., Natarajan, Viswanathan, Salgia, Ravi, Posadas, Edwin M.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.05.2011
• Subjects: Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Animals; Antineoplastic agents; Biological and medical sciences; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - genetics; Cell Shape - drug effects; Cell Shape - genetics; Gene Expression Regulation, Neoplastic - drug effects; Hepatocyte Growth Factor - genetics; Hepatocyte Growth Factor - metabolism; Humans; Male; Medical sciences; Mice; Mice, Nude; Neoplasm Metastasis; Pharmacology. Drug treatments; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Proto-Oncogene Proteins c-fyn - antagonists & inhibitors; Proto-Oncogene Proteins c-fyn - genetics; Proto-Oncogene Proteins c-fyn - metabolism; Proto-Oncogene Proteins c-fyn - physiology; Proto-Oncogene Proteins c-met - genetics; Proto-Oncogene Proteins c-met - metabolism; Receptors, Growth Factor - genetics; Receptors, Growth Factor - metabolism; RNA, Small Interfering - pharmacology; Signal Transduction - drug effects; Signal Transduction - genetics; Signal Transduction - physiology; Tropism - drug effects; Tropism - genetics; Xenograft Model Antitumor Assays; Tropism; Signal transduction; Shape; Hepatocyte growth factor; Cell; In vitro; Protooncogene; Tumor suppressor gene

Purpose: Fyn is a member of the Src family of kinases that we have previously shown to be overexpressed in prostate cancer. This study defines the biological impact of Fyn inhibition in cancer using a PC3 prostate cancer model. Experimental Design: Fyn expression was suppressed in PC3 cells using an...