Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter residues in the enzyme active sites and confer a gain-of-function in cancer cells, resulting in the accumulation and secretion of the oncometabolite...
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Published in | Science (American Association for the Advancement of Science) Vol. 340; no. 6132; pp. 622 - 626 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for the Advancement of Science
03.05.2013
The American Association for the Advancement of Science AAAS |
Subjects | |
Online Access | Get full text |
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