On the role of cystatin C in cancer progression

• Published in: Life sciences (1973) Vol. 202; pp. 152 - 160
• Main Authors: Leto, Gaetano, Crescimanno, Marilena, Flandina, Carla
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2018; Elsevier BV
• Subjects: Anticancer properties; Antitumor activity; Cancer; Cancer therapies; Cathepsins; clinical trials; Cystatin C; Cysteine; Cysteine proteinase; cysteine proteinase inhibitors; Cysteine proteinases; Cysts; disease course; humans; Inhibitors; Metastasis; neoplasms; Protease inhibitors; Proteinase; Proteinase inhibitors; Proteins; Tumor suppressor genes; Tumors; Cathepsins; Cysteine proteinases; Proteinase inhibitors; Metastasis; Cystatin C; Cancer

Cystatin C (Cyst C) is an endogenous inhibitor of lysosomal cysteine proteinases, which has been shown to play a role in several normal and pathological processes. Interestingly, a growing number of experimental and clinical studies suggest that this inhibitor also appears to be implicated in the ma...