SRY‑related HMG box‑2 role in anaplastic thyroid cancer aggressiveness is related to the fibronectin 1 and PI3K/AKT pathway

• Published in: Molecular medicine reports Vol. 21; no. 3; pp. 1201 - 1207
• Main Authors: Wang, Peng, Shang, Jinbiao, Zhao, Jianqiang, Wang, Kejing, Guo, Liang, Gu, Jialei, Wang, Wendong
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2020; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Biotechnology; Cell adhesion & migration; Cell cycle; Cell growth; Cell migration; Cell viability; China; Complementary DNA; Fibronectin; Fibronectins; Gene regulation; Genes; Genetic regulation; Health aspects; Immunoglobulins; Invasiveness; Laboratories; Life sciences; Metastasis; Mortality; Novels; Phenotypes; Polymerase chain reaction; Proteins; Reverse transcription; RNA; Scientific equipment industry; Signal transduction; siRNA; Sox2 protein; Therapeutic applications; Thyroid cancer; Thyroid diseases; Transcription (Genetics); Tumors; United States; Western blotting; Wound healing; United States; China

Anaplastic thyroid cancer (ATC) is a rare thyroid tumor associated with high mortality rates; thus, the identification of novel molecular targets and the development of therapeutic strategies are urgently required. The present study aimed to investigate the role of SRY‑related HMG box‑2 (SOX2) in AT...