A two step synthesis of a key unit B precursor of cryptophycins by asymmetric hydrogenation

• Published in: Beilstein journal of organic chemistry Vol. 7; no. 1; pp. 243 - 245
• Main Authors: Sammet, Benedikt, Brax, Mathilde, Sewald, Norbert
• Format: Journal Article
• Language: English
• Published: Germany Beilstein-Institut 22.02.2011
• Subjects: amino acid; asymmetric hydrogenation; Chemistry; cryptophycin; DuPhos; Full Research Paper; amino acid; DuPhos; cryptophycin; asymmetric hydrogenation

A novel highly enantioselective two step access to a unit B precursor of cryptophycins in good yields from commercially available starting materials has been developed. The key step is an asymmetric hydrogenation using the commercially available [(COD)Rh-( R , R )-Et-DuPhos]BF 4 catalyst. The synthe...