Metabolism-based drug discovery in zebrafish: An emerging strategy to uncover new anti-seizure therapies

• Published in: Neuropharmacology Vol. 167; p. 107988
• Main Authors: Ibhazehiebo, Kingsley, Rho, Jong M., Kurrasch, Deborah M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2020
• Subjects: Animals; Anticonvulsant; Anticonvulsants - pharmacology; Anticonvulsants - therapeutic use; Antiepileptic drug; Bioenergetics; Disease Models, Animal; Drug Discovery - methods; Drug Evaluation, Preclinical - methods; Energy Metabolism - drug effects; Energy Metabolism - physiology; Epilepsy; Experimental therapeutics; Humans; Ketogenic diet; Metabolism; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Seizures - drug therapy; Seizures - metabolism; Zebrafish; Antiepileptic drug; Experimental therapeutics; Mitochondria; Bioenergetics; Epilepsy; Anticonvulsant; Metabolism; Ketogenic diet

As one of the most common neurological disorders, epilepsy can occur throughout the lifespan and from a multiplicity of causes, including genetic mutations, inflammation, neurotrauma, or brain malformations. Although pharmacological agents are the mainstay of treatment for seizure control, an unyiel...