HIV-1 Single-Stranded RNA Induces CXCL13 Secretion in Human Monocytes via TLR7 Activation and Plasmacytoid Dendritic Cell–Derived Type I IFN

• Published in: The Journal of immunology (1950) Vol. 194; no. 6; pp. 2769 - 2775
• Main Authors: Cohen, Kristen W, Dugast, Anne-Sophie, Alter, Galit, McElrath, M Juliana, Stamatatos, Leonidas
• Format: Journal Article
• Language: English
• Published: United States 15.03.2015
• Subjects: Anti-Retroviral Agents - therapeutic use; Cells, Cultured; Chemokine CXCL13 - genetics; Chemokine CXCL13 - immunology; Chemokine CXCL13 - secretion; Cohort Studies; Dendritic Cells - immunology; Dendritic Cells - metabolism; Flow Cytometry; Gene Expression - immunology; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - genetics; HIV-1 - immunology; Host-Pathogen Interactions - drug effects; Host-Pathogen Interactions - immunology; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Imidazoles - pharmacology; Interferon-alpha - immunology; Interferon-alpha - metabolism; Interferon-alpha - pharmacology; Lentivirus; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - virology; Monocytes - immunology; Monocytes - metabolism; Monocytes - virology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral - genetics; RNA, Viral - immunology; Toll-Like Receptor 7 - agonists; Toll-Like Receptor 7 - immunology; Toll-Like Receptor 7 - metabolism; Viremia - drug therapy; Viremia - immunology; Viremia - virology

Elevated levels of the chemokine CXCL13 have been observed in the plasma of chronically HIV-1–infected subjects and have been correlated with plasma viremia, which in turn has been linked to progressive dysregulation of humoral responses. In this study we sought to identify mechanisms of CXCL13 indu...