Pb(NO3)2 induces cell apoptosis through triggering of reactive oxygen species accumulation and disruption of mitochondrial function via SIRT3/SOD2 pathways

• Published in: Environmental toxicology Vol. 39; no. 3; pp. 1294 - 1302
• Main Authors: Lin, Hui‐Wen, Lee, Hsiang‐Lin, Shen, Ting‐Jing, Ho, Meng‐Ting, Lee, Yi‐Ju, Wang, Inga, Lin, Ching‐Pin, Chang, Yuan‐Yen
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2024; Wiley Subscription Services, Inc
• Subjects: Accumulation; Apoptosis; Caspase-3; cell apoptosis; Cell death; Cells; Disulfide reductase; ecotoxicology; Glutathione; glutathione-disulfide reductase; Humans; Hydrogen peroxide; Lead; Lung cancer; Lung carcinoma; lung neoplasms; Lungs; Membrane potential; Mitochondria; Mitochondria - metabolism; mitochondrial; mitochondrial membrane; Mortality; Neoplasms; oxidoreductive activity; Oxygen; Pb(NO3)2; Reactive oxygen species; Reactive Oxygen Species - metabolism; Reductases; ROS; Sirtuin 3 - metabolism; sirtuins; Superoxide dismutase; Superoxide Dismutase - metabolism; toxicity; cell apoptosis; mitochondrial; oxidoreductive activity; Pb(NO3)2; ROS

Lead (Pb) is nonbiodegradable and toxic to the lungs. To investigate the potential mechanisms of Pb‐induced reactive oxygen species (ROS) accumulation and cell death in the lungs, human non‐small lung carcinoma H460 cells were stimulated with Pb(NO3)2 in this study. The results showed that Pb(NO3)2...