fMLP causes degranulation followed by regranulation in rat nasal glands

• Published in: The Laryngoscope Vol. 113; no. 11; p. 1998
• Main Authors: Kim, Seon-Tae, Nakanaga, Takashi, Ueki, Iris, Nadel, Jay A
• Format: Journal Article
• Language: English
• Published: United States 01.11.2003
• Subjects: Animals; Cell Degranulation - drug effects; ErbB Receptors - metabolism; Granulation Tissue - cytology; Granulation Tissue - drug effects; Granulation Tissue - metabolism; Immunohistochemistry; Male; N-Formylmethionine Leucyl-Phenylalanine - adverse effects; Nasal Mucosa - drug effects; Nasal Mucosa - metabolism; Nasal Mucosa - pathology; Neutrophils - physiology; Rats; Rats, Inbred F344; Receptor, ErbB-2 - metabolism

To determine the mechanism of mucus production by nasal glands. Because neutrophilic inflammation is associated with mucus hypersecretion in disease states, here we examine the role of neutrophil recruitment in mucous cell degranulation and regranulation in rat nasal glands. N-formyl-methionyl-leucy...