Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling

• Published in: Journal of veterinary pharmacology and therapeutics Vol. 34; no. 4; pp. 338 - 349
• Main Authors: FOSSE, T. K., TOUTAIN, P. L., SPADAVECCHIA, C., HAGA, H. A., HORSBERG, T. E., RANHEIM, B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011; Wiley-Blackwell
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Body Temperature; Female; Fever - chemically induced; Fever - drug therapy; Fever - veterinary; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - veterinary; Kaolin; Ketoprofen - chemistry; Ketoprofen - pharmacokinetics; Ketoprofen - therapeutic use; Life Sciences; Male; Models, Biological; Pain - drug therapy; Pain - veterinary; Pain Measurement - veterinary; Swine - metabolism; Swine Diseases - chemically induced; Swine Diseases - drug therapy; Swine Diseases - metabolism; ketoprofen; pharmacokinetics; pharmacodynamics

Fosse, T. K., Toutain, P. L., Spadavecchia, C., Haga, H. A., Horsberg, T. E., Ranheim, B. Ketoprofen in piglets: enantioselective pharmacokinetics, pharmacodynamics and PK/PD modelling. J. vet. Pharmacol. Therap.34, 338–349. The chiral pharmacokinetics and pharmacodynamics of ketoprofen were investi...