Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

• Published in: ChemistrySelect (Weinheim) Vol. 3; no. 45; pp. 12824 - 12829
• Main Authors: Dürr, Eva‐Maria, Doherty, William, Lee, Sook Y., El‐Sagheer, Afaf H., Shivalingam, Arun, McHugh, Peter J., Brown, Tom, McGouran, Joanna F.
• Format: Journal Article
• Language: English
• Published: Germany 06.12.2018
• Subjects: 5’-modification; Exonuclease; metalloenzyme; oligonucleotide; squaramide; Exonuclease; metalloenzyme; squaramide; 5’-modification; oligonucleotide

Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in therapeutics and in biological tools. We present the synthesis of N‐oxyam...