Imbalanced suppression of excitatory and inhibitory synaptic transmission onto mouse striatal projection neurons during induction of anesthesia with sevoflurane in vitro

• Published in: The European journal of neuroscience Vol. 35; no. 9; pp. 1396 - 1405
• Main Authors: Oose, Yoshiyuki, Miura, Masami, Inoue, Ritsuko, Andou, Nozomi, Aosaki, Toshihiko, Nishimura, Kinya
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2012
• Subjects: Alveoli; Anesthesia; Anesthetics - pharmacology; Animals; Animals, Newborn; brain slice; Brain slice preparation; CA1 Region, Hippocampal - cytology; Cadmium Chloride - pharmacology; Calcium; Calcium Channel Blockers - pharmacology; Cerebral Cortex - cytology; Corpus Striatum - cytology; Cortex; Dose-Response Relationship, Drug; excitatory postsynaptic currents; Excitatory postsynaptic potentials; Excitatory Postsynaptic Potentials - drug effects; gamma -Aminobutyric acid; Hippocampus; In Vitro Techniques; inhibitory postsynaptic currents; Inhibitory postsynaptic potentials; Inhibitory Postsynaptic Potentials - drug effects; Methyl Ethers - pharmacology; Mice; Mice, Inbred BALB C; Neostriatum; Nervous system; Neurons - drug effects; patch-clamp; Patch-Clamp Techniques; Pyramidal cells; Reaction Time - drug effects; Sevoflurane; spiny neurons; Synaptic transmission; Time Factors

Suppression of movement during induction of anesthesia is mediated through subcortical structures. We studied the effects of a brief, 5‐min application of a clinically relevant concentration of sevoflurane (two minimum alveolar concentration) on the electrophysiological activities of the medium spin...