Inhalation Carcinogenicity of Trichloroethylene in Mice and Rats
Inhalation exposure of guaranteed reagent grade trichloroethylene was performed in female ICR mice and female SD rats at 50, 150 and 450 ppm for 7 hours a day, 5 days a week, for 104 weeks followed by an observation period of 3 weeks. Tumors were distributed mainly in the hematopoietic systems, lung...
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| Published in | Industrial Health Vol. 21; no. 4; pp. 243 - 254 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
National Institute of Occupational Safety and Health
1983
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| Abstract | Inhalation exposure of guaranteed reagent grade trichloroethylene was performed in female ICR mice and female SD rats at 50, 150 and 450 ppm for 7 hours a day, 5 days a week, for 104 weeks followed by an observation period of 3 weeks. Tumors were distributed mainly in the hematopoietic systems, lungs and mammary glands in the mice, and in the pituitary glands and mammary glands in the rats, while several types of tumors were observed in other organs at low inci-dences. The average number of lung tumors per mouse in mice exposed to 150 ppm or 450 ppm was more than 3-fold the incidence in control mice. The incidences of pulmonary adenocarcinomas in mice exposed to 150 ppm and 450 ppm were 16% and 15%, respectively, which was significantly (p<0.05) higher than that of the controls (2%). No significant differences in the incidences of other types of tumors, tumors of specific organs by site of origin or numbers of animals with tumors were recognized between the controls and dosed groups of mice and rats. |
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| AbstractList | Inhalation exposure of guaranteed reagent grade trichloroethylene was performed in female ICR mice and female SD rats at 50, 150 and 450 ppm for 7 hours a day, 5 days a week, for 104 weeks followed by an observation period of 3 weeks. Tumors were distributed mainly in the hematopoietic systems, lungs and mammary glands in the mice, and in the pituitary glands and mammary glands in the rats, while several types of tumors were observed in other organs at low inci-dences. The average number of lung tumors per mouse in mice exposed to 150 ppm or 450 ppm was more than 3-fold the incidence in control mice. The incidences of pulmonary adenocarcinomas in mice exposed to 150 ppm and 450 ppm were 16% and 15%, respectively, which was significantly (p<0.05) higher than that of the controls (2%). No significant differences in the incidences of other types of tumors, tumors of specific organs by site of origin or numbers of animals with tumors were recognized between the controls and dosed groups of mice and rats. |
| Author | FUKUDA, Kazuo TSURUTA, Hiroshi TAKEMOTO, Kazuo |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6654707$$D View this record in MEDLINE/PubMed |
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| References | 3) Golberg, L. (1976). Methyl Chloroform and Trichloroethylene in the Environment, p. 49, CRC Press, Ohio. 11) Drew, R.T. and Laskin, S. (1974). In Methods of Animal Experimentation, Vol. 4 (Edited by Gay, W.I.), p. 16, Academic Press, New York. 16) Konishi, Y., Kawabata, A., Denda, A., Ikeda, T., Katada, H., Maruyama, H. and Higashiguchi, R. (1980). Forestomach tumors induced by orally administered epi-chlorohydrin in male Wistar rats, Gann, 71, 922. 12) Fraser, D.A., Bales, R.E., Lippmann, M. and Stokinger, H.E. (1957). Exposure Cham-bers for Research in Animal Inhalation, Public Health Monograph No. 57, p. 8, U.S. DHEW, U.S. Government Printing Office, Washington, D.C. 9) Tsuruta, H., Iwasaki, K. and Fukuda, K. (1983). Analysis of trace impurities in reagent and technical grade trichloroethylene, Ind. Health, 21, 283. 13) Roe, F.J.C. (1968). In Modern Trends in Toxicology (Edited by Boyland, E. and Gould-ing, R.), p. 39, Butterworths, London. 1) Water, E.M., Gerstner, H.B. and Huff, J.E. (1977). Trichloroethylene. I. An over-view, J. Toxicol. Environ. Health, 2, 671. 20) Kimura, I. (1971). Progression of pulmonary tumors in mice. 1. Histological studies of primary and transformed pulmonary tumors, Acta Pathol. Jpn., 21, 13. 15) Laskin, S., Sellakumar, A.R., Kuschner, M., Nelson, N., La Mendola, S., Rusch, G.M., Katz, G.W., Dulak, N.C. and Albert, R.E. (1980). Inhalation carcinogenicity of epi-chlorohydrin in non-inbred Sprague-Dawley rats, J. Natl. Cancer Inst., 65, 751. 10) Bryan, R.J. (1970). In Inhalation Carcinogenesis (Edited by Hanna, M.G., Nettesheim, P. and Gilbert, J.R.), p. 193, National Technical Information Service, U.S. Department of Commerce, Virginia. 14) Mennear, J. (1982). Memorandum on Trichloroethylene Bioassay Technical Report, Department of Health & Human Services, PHS, NIH, Sept. 14, 1982. 18) Morri, K. (1961). Preliminary note on adenocarcinoma of the lung in mice induced 19) Takayama, S. and Oota, K. (1963). Malignant tumors induced in mice fed with N-nitrosodimethylamine, Gann, 54, 465. 21) Ho, W., Wilcox, K. and Furst, A. (1974). In Experimental Lung Cancer (Edited by Karbe, E. and Park, J.F.), p. 62, Springer-Verlag, Berlin. 23) Tola, S., Vilhunen, R., Jarvinen, E. and Korkala, M-L. (1980). A cohort study on workers exposed to trichloroethylene, J. Occup. Med., 22, 737. 2) Page, N.P. and Arthur, J.L. (1978). Special Occupational Health Hazard Review of Trichloroethylene, DHEW (NIOSH) Publication No. 78-13, U.S. Government printing Office, Washington, D.C. 5) NCI (National Cancer Institute) (1976). Carcinogenesis Bioassay of Trichloroethylene, NCI Carcinogenesis Tech. Rept. Ser. No. 2, NCI-CG-TR-2, DHEW Publ. No. (NIH) 76-802, U.S. Government Printing Office, Washington D.C. 22) Axelson, O., Anderson, K., Hogstedt, C., Holmberg, B., Molina, G. and de Verdier, A. (1978). A cohort study on trichloroethylene exposure and cancer mortality, J. Occup. Med., 20, 194. 8) Henschler, D., Elder, E., Neudecker, T. and Metzler, M. (1977). Carcinogenicity of trichloroethylene : fact or artifacts? Arch. Toxicol., 37, 233. 25) IARC (1982). IARC Monographs on the Evaluation of the Carcinogenic Risk of Che-micals to Humans, Supplement 4. p. 247, IARC, Lyon. 24) Blair, A. (1980). Mortality among workers in the metal polishing and plating industry, 1951-1979. J. Occup. Med., 22, 158. 7) IARC (1979). IARC Monographs on the Evaluation of the Carcinogenic Risk of Che-micals to Humans, Vol. 20, p. 545, IARC, Lyon. 4) Van Durren, B.L. (1975). On the possible mechanism of carcinogenic action of vinyl chloride, Ann. N.Y. Acad. Sci., 246, 258. 6) Henschler, D., Roman, D., Elsasser, H.M., Reichert, D., Eder, E. and Radwan, Z. (1980). Carcinogenicity study of trichloroethylene by long-term inhalation in three animal species, Arch. Toxicol., 43, 237. 17) IARC (1982). IARC Monographs on the Evaluation of the Carcinogenic Risk of Che-micals to Humans, Supplement 4, p. 47, p. 56, IARC, Lyon. with 4-nitroquinoline-N-oxide, Gann, 52, 265. |
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| SubjectTerms | Animals Environmental Exposure Female Key words : Trichloroethylene-Inhalation carcinogenicity-ICR mouse-SD rat-Lung cancer Lung Neoplasms - chemically induced Mammary Neoplasms, Experimental - chemically induced Mice Neoplasms - chemically induced Pituitary Neoplasms - chemically induced Rats Time Factors Trichloroethylene - administration & dosage Trichloroethylene - toxicity |
| Title | Inhalation Carcinogenicity of Trichloroethylene in Mice and Rats |
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