Development and Clinical Application of Phosphorus-Containing Drugs

• Published in: Medicine in drug discovery Vol. 8; p. 100063
• Main Authors: Yu, Hanxiao, Yang, He, Shi, Enxue, Tang, Wenjun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020; The Authors. Published by Elsevier B.V; Elsevier
• Subjects: Drug modification; Phosphite, phosphate; Phosphorus-containing drugs; Prodrugs; Review; Phosphorus-containing drugs; Prodrugs; Phosphite, phosphate; Drug modification

Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates,...