Development and Clinical Application of Phosphorus-Containing Drugs

Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates,...

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Published inMedicine in drug discovery Vol. 8; p. 100063
Main Authors Yu, Hanxiao, Yang, He, Shi, Enxue, Tang, Wenjun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2020
The Authors. Published by Elsevier B.V
Elsevier
Subjects
Drug modification
Phosphite, phosphate
Phosphorus-containing drugs
Prodrugs
Review
Phosphorus-containing drugs
Prodrugs
Phosphite, phosphate
Drug modification
Online AccessGet full text

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Abstract Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.
AbstractList Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.
Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few promising molecules at clinical studies, with particular emphasis on their structural features, biological mechanism, and indications.
ArticleNumber 100063
Author Yang, He
Tang, Wenjun
Shi, Enxue
Yu, Hanxiao
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  surname: Yu
  fullname: Yu, Hanxiao
  organization: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China
– sequence: 2
  givenname: He
  surname: Yang
  fullname: Yang, He
  email: yanghe@sioc.ac.cn
  organization: Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen, 518055, China
– sequence: 3
  givenname: Enxue
  surname: Shi
  fullname: Shi, Enxue
  email: exshi@sina.com
  organization: State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China
– sequence: 4
  givenname: Wenjun
  surname: Tang
  fullname: Tang, Wenjun
  email: tangwenjun@sioc.ac.cn
  organization: State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China
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Keywords Phosphorus-containing drugs
Prodrugs
Phosphite, phosphate
Drug modification
Language English
License This is an open access article under the CC BY-NC-ND license.
2020 The Authors.
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Snippet Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the...
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SubjectTerms Drug modification
Phosphite, phosphate
Phosphorus-containing drugs
Prodrugs
Review
Title Development and Clinical Application of Phosphorus-Containing Drugs
URI https://dx.doi.org/10.1016/j.medidd.2020.100063
https://www.ncbi.nlm.nih.gov/pubmed/32864606
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