Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures

• Published in: The Journal of biological chemistry Vol. 289; no. 23; pp. 16565 - 16575
• Main Authors: Miyamoto, Tatsuya, Mochizuki, Tsutomu, Nakagomi, Hiroshi, Kira, Satoru, Watanabe, Masaki, Takayama, Yasunori, Suzuki, Yoshiro, Koizumi, Schuichi, Takeda, Masayuki, Tominaga, Makoto
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Adenosine Triphosphate - metabolism; Animals; ATP; Calcium; Calcium - metabolism; Cell Biology; Cells, Cultured; Humans; Ion Channel; Ion Channels - physiology; Ion Transport; Mechanotransduction; Mice; Mice, Inbred C57BL; Transient Receptor Potential Channels (TRP Channels); TRPV Cation Channels - metabolism; Urothelium - metabolism; Mechanotransduction; Ion Channel; Calcium; Transient Receptor Potential Channels (TRP Channels); ATP

The urothelium is a sensory structure that contributes to mechanosensation in the urinary bladder. Here, we provide evidence for a critical role for the Piezo1 channel, a newly identified mechanosensory molecule, in the mouse bladder urothelium. We performed a systematic analysis of the molecular an...