Transchromosomally derived Ig heavy chains

• Published in: The Journal of immunology (1950) Vol. 155; no. 2; pp. 684 - 691
• Main Authors: Knight, KL, Kingzette, M, Crane, MA, Zhai, SK
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.07.1995
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary - analysis; Gene Rearrangement - genetics; Haplotypes; Immunoglobulin A - genetics; Immunoglobulin Class Switching - genetics; Immunoglobulin Heavy Chains - genetics; Molecular Sequence Data; Polymorphism, Genetic - genetics; Rabbits; RNA, Messenger - analysis; RNA, Messenger - genetics; Translocation, Genetic - genetics

During an immune response, activated B cells undergo isotype switching and begin to express isotypes other than IgM and IgD. Isotype switching occurs when downstream C gamma, C alpha, or C epsilon genes are rearranged into the S mu chromosomal region, resulting in the deletion of the region in betwe...