Distinctive Features of Extracellular Vesicles Present in the Gastric Juice of Patients with Gastric Cancer and Healthy Subjects

• Published in: International journal of molecular sciences Vol. 26; no. 12; p. 5857
• Main Authors: Skryabin, Gleb, Enikeev, Adel, Beliaeva, Anastasiia, Galetsky, Sergey, Bagrov, Dmitry, Moiseenko, Andrey, Vnukova, Anna, Imaraliev, Oiatiddin, Karasev, Ivan, Tchevkina, Elena
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.06.2025; MDPI
• Subjects: Adult; Aged; Biomarkers, Tumor - metabolism; Cancer; Cancer patients; Case-Control Studies; Comparative analysis; Cryoelectron Microscopy; Development and progression; Diagnosis; Electron microscopy; Extracellular vesicles; Extracellular Vesicles - metabolism; Extracellular Vesicles - ultrastructure; Female; Gastric cancer; Gastric Juice - metabolism; Healthy Volunteers; Humans; Male; Medical prognosis; Middle Aged; Morphology; Mortality; Nanoparticles; Oncology, Experimental; Patients; Polymorphism; Sample size; Stomach cancer; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tetraspanin 29 - metabolism; Transmission electron microscopy; United States; Japan; tetraspanins; gastric juice; nanoparticle tracking analysis; gastric cancer; exosomes; CD9; small extracellular vesicles; cryo-electron microscopy

Extracellular vesicles (EVs) are key mediators of intercellular communication and play a vital role in cancer progression. While EVs in the blood are well-studied, those in local body fluids, such as gastric juice (GJ), remain underinvestigated. Previously, we first characterized GJ-derived EVs and...