The Splice Variant of the NCOR2 Gene BQ323636.1 Modulates ACSL4 Expression to Enhance Fatty Acid Metabolism and Support of Tumor Growth in Breast Cancer

• Published in: International journal of molecular sciences Vol. 26; no. 11; p. 4989
• Main Authors: Tsoi, Ho, You, Chan-Ping, Cheung, Koei Ho-Lam, Tse, Yin-Suen, Khoo, Ui-Soon
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2025; MDPI
• Subjects: Acetate-CoA Ligase - genetics; Acetate-CoA Ligase - metabolism; Animals; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell growth; Cell Line, Tumor; Cell Proliferation; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Energy; Fatty acids; Fatty Acids - metabolism; Female; Gene Expression Regulation, Neoplastic; Genes; Genetic engineering; Growth; Humans; Lipid Metabolism - genetics; Lipids; Long-Chain-Fatty-Acid-CoA Ligase; MCF-7 Cells; Metabolism; Metabolites; Mice; Mice, Nude; Nuclear Receptor Co-Repressor 2 - genetics; Nuclear Receptor Co-Repressor 2 - metabolism; Oxidation; PPAR gamma - metabolism; Ribonucleotide reductase; RNA; RNA sequencing; Transcription factors; Xenograft Model Antitumor Assays; California; United States; Massachusetts; Texas; Illinois; China; breast cancer; ACSL4; BQ323636.1; lipid metabolism

BQ323636.1 (BQ), a splice variant of NCOR2, is associated with endocrine therapy resistance and poorer prognosis in ER-positive breast cancer. This study investigates the role of BQ in modulating lipid metabolism to support tumor growth. RNA sequencing of BQ-overexpressing breast cancer cells reveal...