Impact of lung remodelling on respiratory mechanics in a model of severe allergic inflammation

• Published in: Respiratory physiology & neurobiology Vol. 160; no. 3; pp. 239 - 248
• Main Authors: Silva, Pedro L, Passaro, Caroline P, Cagido, Viviane R, Bozza, Marcelo, Dolhnikoff, Marisa, Negri, Elnara M, Morales, Maina M.B, Capelozzi, Vera L, Zin, Walter A, Rocco, Patricia R.M
• Format: Journal Article
• Language: English
• Published: Amsterdarm Elsevier B.V 29.02.2008; Elsevier
• Subjects: Animals; Asthma - chemically induced; Asthma - pathology; Asthma - physiopathology; Biological and medical sciences; Collagen fibres; Disease Models, Animal; Dose-Response Relationship, Drug; Elastance; Eosinophil; Extracellular matrix; Fundamental and applied biological sciences. Psychology; Hyperplasia - pathology; Hypertrophy - pathology; Lung histology; Lung viscoelasticity; Mammals; Mechanics of breathing; Medical Education; Methacholine Chloride - pharmacology; Mice; Mice, Inbred BALB C; Microscopy, Electron - methods; Muscarinic Agonists - pharmacology; Muscle, Smooth - pathology; Muscle, Smooth - ultrastructure; Ovalbumin - adverse effects; Pathology; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - pathology; Pulmonary Alveoli - ultrastructure; Pulmonary Eosinophilia - pathology; Pulmonary/Respiratory; Respiratory Hypersensitivity - chemically induced; Respiratory Hypersensitivity - pathology; Respiratory Hypersensitivity - physiopathology; Respiratory Mechanics - drug effects; Respiratory Mechanics - physiology; Vertebrates: respiratory system; Elastance; Pathology; Lung histology; Mechanics of breathing; Collagen fibres; Lung viscoelasticity; Extracellular matrix; Mice; Mammals; Eosinophil; Viscoelasticity; Lung; Glycoprotein; Rodentia; Histology; Inflammation; Respiratory system; Vertebrata; Mammalia; Mouse; Collagen; Mechanic of breathing; Models

Abstract We developed a model of severe allergic inflammation and investigated the impact of airway and lung parenchyma remodelling on in vivo and in vitro respiratory mechanics. BALB/c mice were sensitized and challenged with ovalbumin in severe allergic inflammation (SA) group. The control group (...