Uric acid: a modulator of prostate cells and activin sensitivity

• Published in: Molecular and cellular biochemistry Vol. 414; no. 1-2; pp. 187 - 199
• Main Authors: Sangkop, Febbie, Singh, Geeta, Rodrigues, Ely, Gold, Elspeth, Bahn, Andrew
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2016; Springer; Springer Nature B.V
• Subjects: Activins - metabolism; Biochemistry; Biomedical and Life Sciences; Cardiology; Cell Line, Tumor; Cytokines; Glucose Transport Proteins, Facilitative - genetics; Glucose Transport Proteins, Facilitative - metabolism; Growth regulators; Humans; Inflammation; Life Sciences; Male; Medical Biochemistry; Oncology; Probenecid; Probenecid - pharmacology; Prostate - cytology; Prostate - metabolism; Prostate cancer; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Protein expression; Rheumatism; RNA, Messenger - metabolism; Tissue Array Analysis; Transforming Growth Factor beta - metabolism; Uric acid; Uric Acid - metabolism; TGFβ; GLUT9; Hyperuricaemia; Gout; SUA; Probenecid

Elevated serum uric acid (SUA) or urate is associated with inflammation and gout. Recent evidence has linked urate to cancers, but little is known about urate effects in prostate cancer. Activins are inflammatory cytokines and negative growth regulators in the prostate. A hallmark of prostate cancer...