Actin isoforms and reorganization of adhesion junctions in epithelial-to-mesenchymal transition of cervical carcinoma cells

• Published in: Biochemistry (Moscow) Vol. 77; no. 11; pp. 1266 - 1276
• Main Authors: Shagieva, G. S., Domnina, L. V., Chipysheva, T. A., Ermilova, V. D., Chaponnier, C., Dugina, V. B.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01.11.2012; Springer; Springer Nature B.V
• Subjects: Actin; Actin Cytoskeleton; Actins - chemistry; Actins - metabolism; Adherens Junctions - drug effects; Adherens Junctions - metabolism; Adhesion; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cadherins - metabolism; Cancer; Carcinoma; Cell adhesion & migration; Cell Line, Tumor; Cervical cancer; Cytoskeleton; Down-Regulation; Epidermal Growth Factor - pharmacology; Epithelial-Mesenchymal Transition; Female; Humans; Life Sciences; Microbiology; Muscle proteins; Protein Isoforms - chemistry; Protein Isoforms - metabolism; Proteins; Snail Family Transcription Factors; Stem cells; Transcription Factors - metabolism; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Vimentin - metabolism; cytoplasmic actin isoforms; E-cadherin; cervical carcinoma; epithelial-to-mesenchymal transition

Malignant cell transformation requires changes in the ability of cells to migrate. The disruption of actin cytoskeleton and intercellular adhesions is an important component of the acquisition of invasive properties in epithelial malignancies. The invasive ability of carcinoma cells is associated wi...