Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation

• Published in: Frontiers in oncology Vol. 10; p. 592455
• Main Authors: Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu, Hooper, John D.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 30.10.2020
• Subjects: cancer metabolism; cancer therapy; chemoresistance; glycogen; immunometabolism; metabolic reprogramming; Oncology

Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological conditions. Glycogen lies at the nexus of diverse processes that promote malignancy, including proliferation, migration, invasion, and chemoresistanc...