Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation

Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological conditions. Glycogen lies at the nexus of diverse processes that promote malignancy, including proliferation, migration, invasion, and chemoresistanc...

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Published inFrontiers in oncology Vol. 10; p. 592455
Main Authors Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu, Hooper, John D.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 30.10.2020
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Abstract Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological conditions. Glycogen lies at the nexus of diverse processes that promote malignancy, including proliferation, migration, invasion, and chemoresistance of cancer cells. It is also implicated in processes associated with the tumor microenvironment such as immune cell effector function and crosstalk with cancer-associated fibroblasts to promote metastasis. The enzymes of glycogen metabolism are dysregulated in a wide variety of malignancies, including cancers of the kidney, ovary, lung, bladder, liver, blood, and breast. Understanding and targeting glycogen metabolism in cancer presents a promising but under-explored therapeutic avenue. In this review, we summarize the current literature on the role of glycogen in cancer progression and discuss its potential as a therapeutic target for cancer treatment.
AbstractList Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological conditions. Glycogen lies at the nexus of diverse processes that promote malignancy, including proliferation, migration, invasion, and chemoresistance of cancer cells. It is also implicated in processes associated with the tumor microenvironment such as immune cell effector function and crosstalk with cancer-associated fibroblasts to promote metastasis. The enzymes of glycogen metabolism are dysregulated in a wide variety of malignancies, including cancers of the kidney, ovary, lung, bladder, liver, blood, and breast. Understanding and targeting glycogen metabolism in cancer presents a promising but under-explored therapeutic avenue. In this review, we summarize the current literature on the role of glycogen in cancer progression and discuss its potential as a therapeutic target for cancer treatment.
Author He, Yaowu
Kryza, Thomas
Hooper, John D.
Sullivan, Mitchell A.
Lyons, Nicholas
Khan, Tashbib
Gunter, Jennifer H.
AuthorAffiliation 2 Faculty of Health, Australian Prostate Cancer Research Centre-Queensland, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology , Woolloongabba, QLD , Australia
1 Mater Research Institute—The University of Queensland, Translational Research Institute , Woolloongabba, QLD , Australia
AuthorAffiliation_xml – name: 1 Mater Research Institute—The University of Queensland, Translational Research Institute , Woolloongabba, QLD , Australia
– name: 2 Faculty of Health, Australian Prostate Cancer Research Centre-Queensland, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology , Woolloongabba, QLD , Australia
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  givenname: Tashbib
  surname: Khan
  fullname: Khan, Tashbib
– sequence: 2
  givenname: Mitchell A.
  surname: Sullivan
  fullname: Sullivan, Mitchell A.
– sequence: 3
  givenname: Jennifer H.
  surname: Gunter
  fullname: Gunter, Jennifer H.
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  givenname: Thomas
  surname: Kryza
  fullname: Kryza, Thomas
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  surname: Lyons
  fullname: Lyons, Nicholas
– sequence: 6
  givenname: Yaowu
  surname: He
  fullname: He, Yaowu
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  givenname: John D.
  surname: Hooper
  fullname: Hooper, John D.
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This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology
Reviewed by: Domenica Scumaci, Magna Græcia University of Catanzaro, Italy; Angela Ostuni, University of Basilicata, Italy
Edited by: Fatima Baltazar, University of Minho, Portugal
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Snippet Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological...
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SubjectTerms cancer metabolism
cancer therapy
chemoresistance
glycogen
immunometabolism
metabolic reprogramming
Oncology
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Title Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
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