Physical Activity and Risks of Cardiovascular Diseases: A Mendelian Randomization Study

Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal effect remains uncertain. We conducted a Mendelian randomization (MR) study to identify the potential causal effect between physical activity an...

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Published inFrontiers in cardiovascular medicine Vol. 8; p. 722154
Main Authors Zhuo, Chengui, Zhao, Jianqiang, Chen, Miao, Lu, Yunlong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 29.09.2021
Subjects
cardiovascular disease
Cardiovascular Medicine
coronary artery disease
mendelian randomization
myocardial infarction
physical activity
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Abstract Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal effect remains uncertain. We conducted a Mendelian randomization (MR) study to identify the potential causal effect between physical activity and cardiovascular diseases. Methods: Summary statistics of genome-wide association studies on four physical activity phenotypes and cardiovascular diseases were utilized. MR analysis was performed using inverse-variance weighted (IVW) and multivariable MR. Multiple sensitivity analysis was further conducted to identify the robustness of our results. Results: Genetically predicted self-reported vigorous physical activity (VPA) was significantly associated with lower risk of myocardial infarction (IVW OR: 0.24, 95% CI: 0.08–0.68, p -value: 0.007). Additionally, the causal effect of VPA with myocardial infarction was robust after adjusting for several cardiovascular risk factors through using the multivariable MR. There were no apparent causal associations between physical activity with other cardiovascular diseases. Results were consistent with the sensitivity analysis. Conclusion: The present study supports a protective role of self-reported vigorous physical activity in the initiation of myocardial infarction and highlights the importance of activity levels of physical activity. Further studies are required to elucidate the potential biological pathways of physical activity with cardiovascular diseases.
AbstractList Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal effect remains uncertain. We conducted a Mendelian randomization (MR) study to identify the potential causal effect between physical activity and cardiovascular diseases.Methods: Summary statistics of genome-wide association studies on four physical activity phenotypes and cardiovascular diseases were utilized. MR analysis was performed using inverse-variance weighted (IVW) and multivariable MR. Multiple sensitivity analysis was further conducted to identify the robustness of our results.Results: Genetically predicted self-reported vigorous physical activity (VPA) was significantly associated with lower risk of myocardial infarction (IVW OR: 0.24, 95% CI: 0.08–0.68, p-value: 0.007). Additionally, the causal effect of VPA with myocardial infarction was robust after adjusting for several cardiovascular risk factors through using the multivariable MR. There were no apparent causal associations between physical activity with other cardiovascular diseases. Results were consistent with the sensitivity analysis.Conclusion: The present study supports a protective role of self-reported vigorous physical activity in the initiation of myocardial infarction and highlights the importance of activity levels of physical activity. Further studies are required to elucidate the potential biological pathways of physical activity with cardiovascular diseases.
Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal effect remains uncertain. We conducted a Mendelian randomization (MR) study to identify the potential causal effect between physical activity and cardiovascular diseases. Methods: Summary statistics of genome-wide association studies on four physical activity phenotypes and cardiovascular diseases were utilized. MR analysis was performed using inverse-variance weighted (IVW) and multivariable MR. Multiple sensitivity analysis was further conducted to identify the robustness of our results. Results: Genetically predicted self-reported vigorous physical activity (VPA) was significantly associated with lower risk of myocardial infarction (IVW OR: 0.24, 95% CI: 0.08–0.68, p -value: 0.007). Additionally, the causal effect of VPA with myocardial infarction was robust after adjusting for several cardiovascular risk factors through using the multivariable MR. There were no apparent causal associations between physical activity with other cardiovascular diseases. Results were consistent with the sensitivity analysis. Conclusion: The present study supports a protective role of self-reported vigorous physical activity in the initiation of myocardial infarction and highlights the importance of activity levels of physical activity. Further studies are required to elucidate the potential biological pathways of physical activity with cardiovascular diseases.
Author Lu, Yunlong
Zhao, Jianqiang
Chen, Miao
Zhuo, Chengui
AuthorAffiliation 1 Department of Cardiology, Taizhou Central Hospital (Taizhou University Hospital) , Taizhou , China
2 Department of Cardiology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine , Zhejiang , China
3 Department of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou , China
AuthorAffiliation_xml – name: 2 Department of Cardiology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine , Zhejiang , China
– name: 3 Department of Cardiology and Atrial Fibrillation Center, The First Affiliated Hospital, College of Medicine, Zhejiang University , Hangzhou , China
– name: 1 Department of Cardiology, Taizhou Central Hospital (Taizhou University Hospital) , Taizhou , China
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Reviewed by: Petri Böckerman, University of Jyväskylä, Finland; Patricia Kim Phuong Nguyen, Stanford Healthcare, United States
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Snippet Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal...
Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal...
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SubjectTerms cardiovascular disease
Cardiovascular Medicine
coronary artery disease
mendelian randomization
myocardial infarction
physical activity
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Title Physical Activity and Risks of Cardiovascular Diseases: A Mendelian Randomization Study
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