Classical complement activation on human erythrocytes in subjects with systemic lupus erythematosus and a history of autoimmune hemolytic anemia

• Published in: Lupus Vol. 29; no. 10; pp. 1179 - 1188
• Main Authors: Hair, Pamela, Goldman, Daniel W, Li, Jessica, Petri, Michelle, Krishna, Neel, Cunnion, Kenji
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.09.2020; Sage Publications Ltd
• Subjects: Anaphylatoxins; Anemia; Antibodies; Antigen-antibody complexes; Autoimmune hemolytic anemia; Complement activation; Complement component C5a; Enzyme-linked immunosorbent assay; Erythrocytes; Hemolytic anemia; Lupus; Morbidity; Opsonization; Systemic lupus erythematosus; Autoimmune hemolytic anemia (AIHA); peptide inhibitor of complement C1 (PIC1); systemic lupus erythematosus (SLE)

Introduction Autoimmune hemolytic anemia (AIHA) is a serious manifestation of systemic lupus erythematosus (SLE) associated with significant morbidity and mortality. In order to more fully understand the causative pathways, we utilized sera from subjects with SLE and active AIHA, or a history of AIH...