Lidocaine Modulates Cytokine Production and Reprograms the Tumor Immune Microenvironment to Enhance Anti-Tumor Immune Responses in Gastric Cancer

• Published in: International journal of molecular sciences Vol. 26; no. 7; p. 3236
• Main Authors: Wu, Yi-Ying, Chen, Ming-Shan, Chen, I-Chun, Wu, Feng-Hsu, Liao, Tsai-Ling, Wen, Hsiao-Wei, Nielsen, Brent L., Liu, Hung-Jen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.03.2025; MDPI
• Subjects: Cancer; Care and treatment; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell growth; Cell Line, Tumor; Cytokines; Cytokines - metabolism; Cytotoxicity; Female; Gastric cancer; Humans; Immune response; Immune system; Immunity (Disease); Immunotherapy; Interferon-gamma - metabolism; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lidocaine; Lidocaine - pharmacology; Lymphocytes; Lymphocytes, Tumor-Infiltrating - drug effects; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Male; Middle Aged; Stomach cancer; Stomach Neoplasms - drug therapy; Stomach Neoplasms - immunology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Transforming growth factors; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumors; United States; Taiwan; California; gastric cancer; M1 macrophages; immune response; inflammation; cytokine modulation; tumor-infiltrating immune cells; NF-κB activation; gastrointestinal disease; IFN-γ production; lidocaine

Lidocaine, a local anesthetic, has been shown to modulate immune responses. This study examines its effects on cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy donors and tumor-infiltrating immune cells (TIICs) from gastric cancer patients. PBMCs from healthy donors and...