Lidocaine Modulates Cytokine Production and Reprograms the Tumor Immune Microenvironment to Enhance Anti-Tumor Immune Responses in Gastric Cancer - Wu, Yi-Ying; Chen, Ming-Shan; Chen, I-Chun; Wu, Feng-Hsu; Liao, Tsai-Ling; Wen, Hsiao-Wei; Nielsen, Brent L.; Liu, Hung-Jen (International journal of molecular sciences, 2025)
Keywords: Cancer; Care and treatment; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell growth; Cell Line, Tumor; Cytokines; Cytokines - metabolism; Cytotoxicity; Female; Gastric cancer; Humans; Immune response; Immune system; Immunity (Disease); Immunotherapy; Interferon-gamma - metabolism; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lidocaine; Lidocaine - pharmacology; Lymphocytes; Lymphocytes, Tumor-Infiltrating - drug effects; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Macrophages; Macrophages - drug effects; Macrophages - immunology; Macrophages - metabolism; Male; Middle Aged; Stomach cancer; Stomach Neoplasms - drug therapy; Stomach Neoplasms - immunology; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Transforming growth factors; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumors; United States; Taiwan; California; gastric cancer; M1 macrophages; immune response; inflammation; cytokine modulation; tumor-infiltrating immune cells; NF-κB activation; gastrointestinal disease; IFN-γ production; lidocaine