Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection

• Published in: Frontiers in veterinary science Vol. 7; p. 12
• Main Authors: Goto, Shinya, Konnai, Satoru, Hirano, Yuki, Kohara, Junko, Okagawa, Tomohiro, Maekawa, Naoya, Sajiki, Yamato, Watari, Kei, Minato, Erina, Kobayashi, Atsuhi, Gondaira, Satoshi, Higuchi, Hidetoshi, Koiwa, Masateru, Tajima, Motoshi, Taguchi, Eiji, Uemura, Ryoko, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Yamamoto, Keiichi, Toda, Mikihiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 20.02.2020
• Subjects: immune dysfunction; immunoinhibitory molecules; PD-1; PD-L1; prostaglandin E2; T-cell exhaustion; Veterinary Science

Bovine mycoplasmosis caused by Mycoplasma bovis results in pneumonia and mastitis in cattle. We previously demonstrated that the programmed death 1 (PD-1)/PD-ligand 1 (PD-L1) pathway is involved in immune dysfunction during M. bovis infection and that prostaglandin E2 (PGE2) suppressed immune respon...