Rostrocaudal subregions of the ventral tegmental area are differentially impacted by chronic stress

• Published in: Psychopharmacology Vol. 236; no. 6; pp. 1917 - 1929
• Main Authors: Bambico, Francis Rodriguez, Li, Zhuoliang, Oliveira, Caio, McNeill, Sean, Diwan, Mustansir, Raymond, Roger, Nobrega, José N.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2019; Springer; Springer Nature B.V
• Subjects: Addictions; Animal cognition; Biomedical and Life Sciences; Biomedicine; Brain research; Brain-derived neurotrophic factor; Depression, Mental; Dopamine; Dopamine receptors; EGR-1 protein; Firing pattern; GABA; Glucocorticoid receptors; Glutamatergic transmission; Hedonic response; Hybridization; Hypotheses; Mental depression; Mental health; mRNA; Neurons; Neurophysiology; Neurosciences; Original Investigation; Pathophysiology; Pharmacology/Toxicology; Psychiatry; Psychopharmacology; Receptor mechanisms; RNA; Stress; Stress (Psychology); Sucrose; Ventral tegmentum; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; γ-Aminobutyric acid A receptors; Passive coping; Chronic stress; Dopamine; Forced swim test; Electrophysiology; Depression; Anhedonia; Sucrose preference test; Ventral tegmental area; zif268

Rationale The ventral tegmental area (VTA) is implicated in the pathophysiology of depression and addictive disorders and is subject to the detrimental effects of stress. Chronic stress may differentially alter the activity pattern of its different subregions along the rostrocaudal and dorsoventral...