Interleukin 23 is elevated in the serum of patients with SLE

• Published in: Lupus Vol. 29; no. 14; pp. 1943 - 1947
• Main Authors: Vukelic, Milena, Laloo, Anita, Kyttaris, Vasileios C
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.12.2020; Sage Publications Ltd
• Subjects: Anti-DNA antibodies; Arthritis; Autoantibodies; Cell differentiation; Cytokines; Demography; Enzyme-linked immunosorbent assay; Helper cells; Immunomodulation; Immunomodulators; Inflammation; Interleukin 17; Interleukin 23; Kidneys; Lupus; Lymphocytes T; Serositis; Systemic lupus erythematosus; Systemic Lupus Erythematosus; interleukin 23; nephritis; T helper-17

Aim: Interleukin-23 (IL-23) is a cytokine that promotes the differentiation of T cells into pro-inflammatory Th17. We have previously shown that IL-23 is upregulated in systemic lupus erythematosus (SLE) patients and lupus prone mice. As SLE is highly heterogeneous, we asked whether IL-23 production...