Interleukin 23 is elevated in the serum of patients with SLE

• Published in: Lupus Vol. 29; no. 14; pp. 1943 - 1947
• Main Authors: Vukelic, Milena, Laloo, Anita, Kyttaris, Vasileios C
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.12.2020; Sage Publications Ltd
• Subjects: Anti-DNA antibodies; Arthritis; Autoantibodies; Cell differentiation; Cytokines; Demography; Enzyme-linked immunosorbent assay; Helper cells; Immunomodulation; Immunomodulators; Inflammation; Interleukin 17; Interleukin 23; Kidneys; Lupus; Lymphocytes T; Serositis; Systemic lupus erythematosus; Systemic Lupus Erythematosus; interleukin 23; nephritis; T helper-17
• ISSN: 0961-2033; 1477-0962; 1477-0962
• DOI: 10.1177/0961203320952841

Aim: Interleukin-23 (IL-23) is a cytokine that promotes the differentiation of T cells into pro-inflammatory Th17. We have previously shown that IL-23 is upregulated in systemic lupus erythematosus (SLE) patients and lupus prone mice. As SLE is highly heterogeneous, we asked whether IL-23 production correlates with different manifestations of the disease. Methods: We recruited 56 subjects who fulfilled the ACR criteria for SLE. Interleukin-23 was measured in the serum by ELISA. Results: IL-23 levels were positively correlated with the overall SLE disease activity as measured with the SLEDAI. Moreover, IL-23 correlated with the skin, renal domains of SLEDAI and arthritis but not with cytopenias or serositis. IL-23 did also correlate with anti-dsDNA antibody positivity and inversely correlated with C3 levels. We found no relationship between patients’ demographics, prior disease manifestations, medications, or autoantibody profile and IL-23 levels. No immunomodulatory medication seemed to be affecting IL-23 levels suggesting that current medications used in SLE are not as effective in shutting down the IL-23/IL-17 axis. Conclusions: IL-23 levels track SLE disease activity mostly in the renal, skin and musculoskeletal domains. Our data suggest that IL-23 inhibitors may be helpful in combination with current standard of care in alleviating arthritis, renal and cutaneous manifestations of the disease.