Retinal microglia polarization in diabetic retinopathy

Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role...

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Published inVisual neuroscience Vol. 38; p. E006
Main Authors Li, Xin, Yu, Zi-Wei, Li, Hui-Yao, Yuan, Yue, Gao, Xin-Yuan, Kuang, Hong-Yu
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 03.05.2021
Subjects
Antigen presentation
Cell migration
Central nervous system
Cytokines
Diabetes
Diabetes mellitus
Diabetic retinopathy
Gene expression
Genotype & phenotype
Homeostasis
Hyperglycemia
Inflammation
Microglia
Microglial cells
Microvasculature
Morphology
Neurodegeneration
Pathogenesis
Phagocytosis
Phenotypes
Polarization
Retina
Retinopathy
Tumor necrosis factor-TNF
diabetic retinopathy
retinal microglia
microglia polarization
Online AccessGet full text
ISSN0952-5238
1469-8714
1469-8714
DOI10.1017/S0952523821000031

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Abstract Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.
AbstractList Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.
Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.
ArticleNumber E006
Author Kuang, Hong-Yu
Yuan, Yue
Yu, Zi-Wei
Li, Xin
Gao, Xin-Yuan
Li, Hui-Yao
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  fullname: Yu, Zi-Wei
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  surname: Kuang
  fullname: Kuang, Hong-Yu
  organization: The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
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Snippet Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in...
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SubjectTerms Antigen presentation
Cell migration
Central nervous system
Cytokines
Diabetes
Diabetes mellitus
Diabetic retinopathy
Gene expression
Genotype & phenotype
Homeostasis
Hyperglycemia
Inflammation
Microglia
Microglial cells
Microvasculature
Morphology
Neurodegeneration
Pathogenesis
Phagocytosis
Phenotypes
Polarization
Retina
Retinopathy
Tumor necrosis factor-TNF
Title Retinal microglia polarization in diabetic retinopathy
URI https://www.cambridge.org/core/product/identifier/S0952523821000031/type/journal_article
https://www.ncbi.nlm.nih.gov/pubmed/33934736
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Volume 38
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