The Obesity Related Gene, FTO, Interacts with APOE, and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study

• Published in: Journal of Alzheimer's disease Vol. 23; no. 3; pp. 461 - 469
• Main Authors: Keller, Lina, Xu, Weili, Wang, Hui-Xin, Winblad, Bengt, Fratiglioni, Laura, Graff, Caroline
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2011
• Subjects: Aged; Aged, 80 and over; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; APOE; Apolipoprotein E4 - genetics; Apolipoprotein E4 - metabolism; body mass index; cardiovascular disease; Cohort Studies; dementia; diabetes; Female; Follow-Up Studies; FTO; Humans; Longitudinal Studies; Male; Motor Activity - genetics; Obesity - genetics; Obesity - metabolism; physical activity; Prospective Studies; Proteins - genetics; Proteins - metabolism; Risk Factors; FTO; cardiovascular disease; body mass index; dementia; APOE; Alzheimer's disease; diabetes; physical activity

The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes. Both high BMI and diabetes are vascular risk factors that might play a role in the development of Alzheimer's disease (AD) and dementia. Thus, our aim was to explore the...