A Multi-Level Study on the Anti-Lung Cancer Mechanism of Peiminine, a Key Component of Fritillaria ussuriensis Maxim.: Integrating Quality Analysis, Network Pharmacology, Bioinformatics Analysis, and Experimental Validation

• Published in: International journal of molecular sciences Vol. 26; no. 8; p. 3506
• Main Authors: Yang, Ziwen, Syed Faizan Ali, Shah, Huang, Xinhui, Wei, Lin, Zhong, Yinze, Shi, Xuepeng, Wu, Xiaotian, Gan, Chunli, Wang, Zhibin, Yang, Chunjuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.04.2025; MDPI
• Subjects: Alkaloids; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Bioinformatics; Cancer; Cancer therapies; Care and treatment; Cell cycle; Cell Line, Tumor; Cevanes - chemistry; Cevanes - pharmacology; Chemotherapy; Chromatography; Chromatography, High Pressure Liquid; Computational Biology - methods; Drugs; Enzymes; Fritillaria - chemistry; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetic aspects; Health aspects; Humans; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Molecular Docking Simulation; Network Pharmacology - methods; Pharmacology; Physiological aspects; Protein Interaction Maps - drug effects; Proteins; Radiation therapy; Side effects; Signal Transduction - drug effects; Tandem Mass Spectrometry; Toxicity; Traditional Chinese medicine; China; lung cancer; PI3K–Akt signaling pathway; molecular docking; peiminine; network pharmacology

Globally, lung cancer is the primary cause of deaths associated with cancer; however, current therapies are costly and toxic, highlighting the need for novel treatments. Peiminine (Verticinone), a key bioactive compound derived from Fritillaria ussuriensis Maxim., has demonstrated diverse biological...