A Multi-Level Study on the Anti-Lung Cancer Mechanism of Peiminine, a Key Component of Fritillaria ussuriensis Maxim.: Integrating Quality Analysis, Network Pharmacology, Bioinformatics Analysis, and Experimental Validation - Yang, Ziwen; Syed Faizan Ali, Shah; Huang, Xinhui; Wei, Lin; Zhong, Yinze; Shi, Xuepeng; Wu, Xiaotian; Gan, Chunli; Wang, Zhibin; Yang, Chunjuan (International journal of molecular sciences, 2025)
Keywords: Alkaloids; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Bioinformatics; Cancer; Cancer therapies; Care and treatment; Cell cycle; Cell Line, Tumor; Cevanes - chemistry; Cevanes - pharmacology; Chemotherapy; Chromatography; Chromatography, High Pressure Liquid; Computational Biology - methods; Drugs; Enzymes; Fritillaria - chemistry; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetic aspects; Health aspects; Humans; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Molecular Docking Simulation; Network Pharmacology - methods; Pharmacology; Physiological aspects; Protein Interaction Maps - drug effects; Proteins; Radiation therapy; Side effects; Signal Transduction - drug effects; Tandem Mass Spectrometry; Toxicity; Traditional Chinese medicine; China; lung cancer; PI3K–Akt signaling pathway; molecular docking; peiminine; network pharmacology