Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy?

• Published in: Frontiers in oncology Vol. 11; p. 678562
• Main Authors: van Schaik, Thijs A., Chen, Kok-Siong, Shah, Khalid
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 01.06.2021
• Subjects: damage associated molecular pattern (DAMP); immunogenic; immunotherapy; Oncology; tolerogenic; tumor cell death; tumor microenvironment (TME)

Combinatory treatments using surgery, radiotherapy and/or chemotherapy together with immunotherapy have shown encouraging results for specific subsets of tumors, but a significant proportion of tumors remains unsusceptible. Some of these inconsistencies are thought to be the consequence of an immuno...