Melatonin Promotes Nerve Regeneration Following End-to-Side Neurorrhaphy by Accelerating Cytoskeletal Remodeling via the Melatonin Receptor-dependent Pathway

• Published in: Neuroscience Vol. 429; pp. 282 - 292
• Main Authors: Liu, Chiung-Hui, Chang, Hung-Ming, Yang, Yin-Shuo, Lin, Yu-Ta, Ho, Ying-Jui, Tseng, To-Jung, Lan, Chyn-Tair, Li, Shao-Ti, Liao, Wen-Chieh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.03.2020
• Subjects: Animals; cytoskeletal remodeling; Cytoskeleton; end-to-side neurorrhaphy; melatonin; Melatonin - pharmacology; melatonin receptor; Mice; Nerve Regeneration; Rats; Rats, Wistar; Receptors, Melatonin; β3-tubulin; N2a cells; ESN; β3-tubulin; end-to-side neurorrhaphy; CMAP; MT2; PNI; MT1; MTs; RA; GAP43; CaMKII; McN; UN; melatonin receptor; nerve regeneration; melatonin; cytoskeletal remodeling; MEPs

•Melatonin suppresses activation of calmodulin-dependent protein kinase II (CaMKII) in sprouting axons.•Melatonin regulates cytoskeleton rearrangement via a membrane receptor pathway in neural cells.•Melatonin at physiological concentrations (1–10 nM) causes cytoskeletal changes in regenerated axons...