Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

• Published in: American journal of respiratory and critical care medicine Vol. 183; no. 6; pp. 734 - 742
• Main Authors: Mallia, Patrick, Message, Simon D., Gielen, Vera, Contoli, Marco, Gray, Katrina, Kebadze, Tatiana, Aniscenko, Julia, Laza-Stanca, Vasile, Edwards, Michael R., Slater, Louise, Papi, Alberto, Stanciu, Luminita A., Kon, Onn M., Johnson, Malcolm, Johnston, Sebastian L.
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.03.2011
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma; B. Chronic Obstructive Pulmonary Disease; Biological and medical sciences; Bronchoscopy; Case-Control Studies; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; Disease Progression; Effectiveness; Female; Humans; Infections; Inflammation; Inflammation Mediators - analysis; Intensive care medicine; Investigations; Lavage; Male; Medical sciences; Middle Aged; Models, Biological; Picornaviridae Infections; Pilot projects; Pneumology; Pulmonary Disease, Chronic Obstructive - virology; Rhinovirus; Viral Load; Viruses; United Kingdom > UK; Lung disease; disease exacerbation; Intensive care; Respiratory disease; Picornaviridae; Respiratory system infection; Human rhinovirus; Virus; respiratory tract infections; Bronchus disease; Chronic obstructive pulmonary disease; Resuscitation; Rhinovirus; COPD

Respiratory virus infections are associated with chronic obstructive pulmonary disease (COPD) exacerbations, but a causative relationship has not been proven. Studies of naturally occurring exacerbations are difficult and the mechanisms linking virus infection to exacerbations are poorly understood....