Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study

• Published in: Journal of Korean medical science Vol. 32; no. 8; pp. 1268 - 1274
• Main Authors: Oh, Dong Hyun, Ahn, Jin Young, Kim, Sang Il, Kim, Min Ja, Woo, Jun Hee, Kim, Woo Joo, Baek, Ji Hyeon, Kim, Shin-Woo, Choi, Bo Youl, Lee, Mi Hwa, Choi, Ju-yeon, Han, Myung Guk, Kang, Chun, Kim, June Myung, Choi, Jun Yong
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.08.2017; 대한의학회
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - diagnosis; Adult; Aged; Aged, 80 and over; Anti-Retroviral Agents - therapeutic use; Blood Glucose - analysis; Body Mass Index; Cohort Studies; Dyslipidemias - diagnosis; Dyslipidemias - etiology; HIV Infections - complications; HIV Infections - diagnosis; HIV Infections - drug therapy; Hospitals; Humans; Metabolic Syndrome - diagnosis; Metabolic Syndrome - epidemiology; Metabolic Syndrome - etiology; Middle Aged; Original; Prevalence; Protease Inhibitors - therapeutic use; Republic of Korea - epidemiology; Risk Factors; Young Adult; 의학일반; Metabolic Complication; Protease Inhibitor; Dyslipidemia; HIV Infection
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2017.32.8.1268

Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m², and 16.4% of the patients had a BMI over 25 kg/m². A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.